Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe
Abstract Background We have previously reported that p53 mutated radioresistant lymphoma cell lines undergo mitotic catastrophe after irradiation, resulting in metaphase arrest and the generation of endopolyploid cells.A proportion of these endopolyploid cells then undergo a process of de-polyploidisation, stages of which are partially reminiscent